The Myosin Heavy Chain Mouse Monoclonal Antibody (11C2) from MyBioSource.com is a Mouse Monoclonal antibody to Miscellaneous. This antibody recognizes Human, Mouse, Rat, C. elegans/Worm, Drosophila/Arthropod, and Zebrafish/Fish antigen. The Myosin Heavy Chain Mouse Monoclonal Antibody (11C2) has been validated for the following applications: Immunofluorescence, and Immunohistochemistry.
Description
Background: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Cardiac MHC exists as two isoforms in humans, alpha-cardiac MHC and beta-cardiac MHC. These two isoforms are expressed in different amounts in the human heart. During normal physiology, beta-cardiac MHC is the predominant form, with the alpha-isoform contributing around only 7% of the total MHC. Mutations of the MHC genes are associated with several different dilated and hypertrophic cardiomyopathies